Earticle

초록

영어

Apoptosis is a biological process of cell suicide that plays critical roles in development and homeostasis of metazoan organisms. Apoptosis is activated via the cell-intrinsic and cell-extrinsic signaling pathways. Cancer cells often acquire mutations that enable them to escape proapoptotic signals induced by conventional therapies. Hence, intense efforts have been underway to develop treatment strategies that can overcome hurdles to apoptosis in cancer cells. The cell-extrinsic pathway is triggered at the cell surface via pro-apoptotic death receptors such as DR4 and DR5. Human monoclonal antibodies (MAbs) that activate these receptors display potent activity in various preclinical tumor models, and are studied in cancer clinical trials. We have discovered that Fγ receptors (FγRs), expressed on tumor-infiltrating leukocytes, provide a dynamic cross-linking platform to mediate the apoptosisinducing activity of DR5 MAbs. Our findings provide novel insights into the mechanism of action of death receptor-agonistic MAbs against tumors and suggest that endowing such molecules with stronger FγR binding may further enhance their clinical utility.

저자

• Avi ASHKENAZI [ Senior staff scientists and Director, Dept. of Molecular Oncology, Genentech Inc., USA ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576