Earticle

초록

영어

The quinolones are broad-spectrum antibiotics and enhanced antimicrobial activity has extended the use of the quinolones beyond the traditional indications for quinolone antibiotics in the treatment of urinary tract infections. The quinolones are effective in a wider variety of infectious diseases, including skin and respiratory infections. Because of their excellent safety and tolerability, they have become popular alternatives to penicillin and cephalosporin derivatives in the treatment of various infections. A retrospective study was performed to evaluate efficacy and safety of IV quinolones for inpatient use. Total 117 patients who administerd quinolones for longer than 3 continuous days at community hospital from October 1st, 2008 to December 31st, 2008 were reviewed. The criterias for drug evaluation were included the validation of indication, outcome, dosage and side effects. In the results, ciprofloxacin 13 (total 93), levofloxacin 3 (total 59) and moxifloxacin 2 (total 19) cases were not met the criterias based on the culture results. Major indications were pneumonia (ciprofloxacin 16.3%, levofloxacin 67.8%, moxifloxacin 84.2%), urinary tract infection (ciprofloxacin 44.1%), skin infection (ciprofloxacin 7.5%, levofloxacin 20.3%, moxifloxacin 10.5%), intra-abdominal infection (ciprofloxacin 10.8%, moxifloxacin 5.3%), etc.. In the results of quinolone monotherapy, the frequencies were each ciprofloxacin 74.2%, levofloxacin 50.8% and moxifloxacin 47.4%. In the results of dosage validation, the validities were each ciprofloxacin 54.8%, levofloxacin 94.9% and moxifloxacin 100.0%. In the results of duration validation, the validities were each ciprofloxacin 59.1%, levofloxacin 78.0% and moxifloxacin 89.5%. Adverse drug reactions were reported for total 49 cases and those were gastrointestinal tract effects including nausea, vomiting, diarrhea and central nervous system effects including headache, dizziness. In summary, the quinolones appropriately used for hospitalized patients based on this study. A focused approach emphasizing "correct use of quinolones" may reduce development of antimicrobial resistance and maximize class efficacy. Consequently, correct use of antibiotics will contribute to decrease medical expenses for person and community.

목차

Abstract
 연구 방법
  연구 대상 및 기간
  자료 수집
  치료효과도의 판정
  항균제 사용에 대한 부작용 발생 평가
  통계처리
 연구 결과
  Quinolone계 항균제 투약 환자들의 역학적 특성
  적응증 및 투약 기간
  항균제 사용 전후 발열 및 백혈구 수치 평가
  균배양과 감수성검사 시행유무 및 항균제 사용의 적합성평가
  Serum creatinine 검사와 신기능 평가 및 용량의 적절성평가
  치료효과도의 판정
  항균제 사용에 대한 부작용 발생 평가
 고찰
 결론
 참고 문헌

키워드

저자

• 김훈희 [ Hoon Hee Kim | 충북대학교 약학대학 임상약학실 ]
• 이옥상 [ Ok Sang Lee | 충북대학교 약학대학 임상약학실 ]
• 정선회 [ Sun Hoi Jung | 충북대학교 약학대학 임상약학실 ]
• 임성실 [ Sung Cil Lim | 충북대학교 약학대학 임상약학실 ] Correspondence

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615