Earticle

초록

영어

Bioactive peptides (BAP) showed excellent cosmetic activity than bio-materials such as caffeic acid (CA), gallic acid (GA), and nicotinic acid (NA). Caffeoyl tripeptide-1 (CT-1) is a BAP that is stabilized with Gly-His-Lys (GHK) tripeptide and CA by using Fmoc solid phase peptide synthesis. Digalloyl tetrapeptide-19 (DT-19) is stabilized by combining Lys-Glu-Cys-Gly with GA and nicotinoyl tripeptide-1 (NT-1) is synthesized by GHK and NA. According to experiments, CT-1 has an excellent anti-oxidant function even with a very small amount of 10 ppm CT-1. DT-19’ tyrosinase inhibition activity has the better effect of about 28.57% in 0.01% and 33.33% in 0.005% of concentration and about 7.89% in 0.001% concentration than vitamin-C. In addition, NT-1 is safer than the NA. Almost BAPs like pal-KTTKS, acetyl hexapeptide, and copper tripeptide-1 have the anti-wrinkle effect while DT-19 and NT-1 are applicable for potential BAPs focused on the whitening effect. The three kinds of BAPs like CT-1, DT-19, and NT-1 consisting of amino acids are safe to the skin, and have more excellent stability than bio-materials which are found to be unstable and cause skin irritation. Due to the high biological activity of BAP in the field of skin care, its utilization will increase constantly.

목차

Abstract
 1. 서론
 2. 피부 미용 생리활성 펩타이드의 종류
 3. Fmoc 기반의 고체상 펩타이드 합성법을 이용한 바이오 소재의 안정화
 4. 주요 피부 미용 소재 생리활성 펩타이드의 특징
  4.1. CT-1
  4.2. DT-19
  4.3. NT-1
 5. 결론
 References

키워드

저자

• 모상현 [ Sang Hyun Moh | 주)바이오에프디앤씨 생명과학연구소 ]
• 정대현 [ Dai Hyun Jung | 주)바이오에프디앤씨 생명과학연구소 ]
• 김형식 [ Hyoung Shik Kim | 주)바이오에프디앤씨 생명과학연구소 ]
• 조문진 [ Moon Jin Cho | 주)바이오에프디앤씨 생명과학연구소 ]
• 서효현 [ Hyo Hyun Seo | 주)바이오에프디앤씨 생명과학연구소 ]
• 김성준 [ Sung Jun Kim | 숙명여대 사회교육대학원 미용예술과, 주)제니트리 생명과학연구소 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  KSBB Journal

• 간기

  격월간

• pISSN

  1225-7117

• 수록기간

  2009~2013

• 십진분류

  KDC 476 DDC 576