Earticle

초록

영어

We investigated the antioxidative effect of black garlic extract (BGE) on paraquat (PQ)- induced oxidative stress in mice. A DPPH radical scavenging activity assay showed that BGE had potent free radical scavenging activity, comparable to that exhibited by vitamin C. Mice were administered with either vitamin C or two levels of BGE by oral gavage for 10 days, with PQ being injected intraperitoneally on day five. It was found that BGE reduced the liver enzyme levels induced by PQ injection in mice. The concentrations of plasma and hepatic malonedialdehyde were both significantly reduced in the BGE groups compared with the levels in the PQ group, whereas the hepatic superoxide dismutase and catalase activities were significantly increased in the BGE groups compared with the PQ group. These findings suggest that BGE has potent antioxidative activities in vivo and thus could prevent the oxidative stress induced by PQ injection in mice by two mechanisms: the induction of antixoxidative enzyme systems and direct scavenging of reactive oxygen species.

목차

Abstract
 서론
 재료 및 방법
  실험동물 및 시약
  실험 동물 처리
  분석시료 처리
  혈청 중 간기능 지표효소의 활성도 측정
  자유라디컬 소거 활성 측정
  혈액과 간 조직중의 과산화지질 함량 측정
  항산화효소계 활성측정
  글루타치온 함량 측정
  통계처리
 결과 및 고찰
  DPPH 라디컬 소거능
  마우스 체중의 변화
  혈액 내 간기능 지표 측정
  혈액과 간에서의 지질과산화물 함량 변화
  간 조직 내 항산화 효소 활성 변화
  간 조직 내 글루타치온 함량 측정
 요약
 감사의 글
 문헌

키워드

저자

• 노병규 [ Byung-Kyu Noh | 고려대학교 생명과학대학 식품공학부 ]
• 이정규 [ Jung Kyu Lee | 고려대학교 생명과학대학 식품공학부 ]
• 원용덕 [ Yong-Duk Won | 의성흑마늘 영농조합 ]
• 박현진 [ Hyun-Jin Park | 고려대학교 생명과학대학 식품공학부 ]
• 이성준 [ Sung-Joon Lee | 고려대학교 생명과학대학 식품공학부 ] Corresponding author

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국식품과학회지 [Korean Journal of Food Science and Technology]

• 간기

  격월간

• pISSN

  0367-6293

• 수록기간

  1969~2011

• 십진분류

  KDC 574 DDC 664