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신장이식 후 Cyclosporine 혈중농도와 거부반응 및 신동성과의 관계
The Relationship between Cyclosporine Through Concentrations and Allograft Rejection and Renal Toxicity after Renal Transplantation
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- 발행기관
- 한국임상약학회 바로가기
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- 간행물
- 한국임상약학회지 KCI 등재후보 바로가기
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- 통권
- 제13권 제1호 (2003.06)바로가기
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- 페이지
- pp.1-4
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- 저자
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- 언어
- 한국어(KOR)
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- URL
- https://www.earticle.net/Article/A1606
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원문정보
초록
- 영어
- Cyclosporine (CsA) has become well established as a potent immunosuppressive agent in the renal transplantation. However, therapy is complicated by large intraindividual and interindividual variability in pharmacokinetics of CsA and frequent undesirable clinical outcomes such as graft rejection and nephrotoxicity. The objective of this study was to determine the CsA trough blood concentrations that were associated with acute graft rejection and renal toxicity in renal transplant patients. Also, the ability of the current recommendation of therapeutic range for CsA to prevent graft rejections and CsA-associated renal toxicity was assessed. The clinical courses of the patients on CsA as an immusuppressive agent for preventing the graft rejection with renal ransplantation performed at Seoul National University Hospital from January 1995 to September 1998 were retrospectively reviewed. Total of 78 patients were included and three of them were retransplantation cases. Twenty-two acute episodes of rejection were identified, but only 16 episodes were clinically significant. Of these all the episodes occurred during the first month after transplantation except one. Mean daily doses of CsA were at posttransplant 1, 3, 6, and 12 months, respectively. Mean CsA whole blood though levels were at posttransplant 1, 3, 6 and 12 months, respectively. Mean daily doses/weight were at posttransplant 1, 3, 6 and 12 months, respectively. CsA doses decreased significantly as months progressed (p<0.001). During the first month after transplantation, only of the patients in rejection group had CsA concentration in therapeutic range, and 87.5, 93.8, and were within the therapeutic range at posttransplant 3, 6, and 12 months, respectively. These results suggested that CsA concentrations of might be appropriate for preventing the acute rejection during the first posttransplant month.
키워드
Cyclosporine Renal Transplantation Allograft Rejection Through Concentrations Neph-rotoxicity저자
간행물 정보
발행기관
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- 발행기관명
- 한국임상약학회 [Korean College of Clinical Pharmacy]
- 설립연도
- 1
- 분야
- 의약학>약학
- 소개
- 합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.
간행물
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- 간행물명
- 한국임상약학회지 [Korean Journal of Clinical Pharmacy]
- 간기
- 계간
- pISSN
- 1226-6051
- 수록기간
- 1991~2026
- 등재여부
- KCI 등재
- 십진분류
- KDC 518 DDC 615
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