Earticle

초록

영어

Alginate bead has been supplemented with various polymers to control permeability and to enhance mechanical strength. In this report, fibroin-reinforced alginate hydrogel was prepared, in which spatial localization of fibroin molecules was investigated. Confocal laser scanning microscopy revealed that fibroin molecules formed a fibrous network in the alginate-fibroin beads, which was expected to enhance mechanical strength as same as in many composite materials. Uniaxial compression test showed that fibroin-reinforced alginate beads had increased mechanical strength only after methanol treatment that caused β-sheet formation among fibroin molecules. Simultaneous curing and dialysis of alginate beads were carried out to remove excesscalcium but to retain fibroin in the dialysis chamber, which fabricated beads without internal fibrous fluorescent stains. Fibroin molecules were only found beneath the surface of the beads. The fibroin-diffused shell was further processed to form a thick wall after drying or was mobilizedto the centre of the bead by methanol treatment. Accordingly, the structure analyses provide processing methods of fibroin to form a wall or center clumps, which could be applied to design controlled delivery device.

목차

Abstract
 1. 서론
 2. 재료 및 방법
  2.1. 알긴산 하이드로겔 비드 및 캡슐의 제조
  2.2. 알긴산 비드 및 캡슐의 분석
 3. 결과 및 고찰
  3.1. 알긴산-피브로인 비드의 제조 및 분석
  3.2. 투석을 병행한 알긴산-피브로인 캡슐
  3.3. 다양한 구조를 가진 알긴산-피브로인 건조 비드의 제조
 감사
 References

키워드

저자

• 이진실 [ Jin Sil Lee | 강원대학교 공과대학 생물공학과 ]
• 이신영 [ Shin-Young Lee | 강원대학교 공과대학 생물공학과 ]
• 허원 [ Won Hur | 강원대학교 공과대학 생물공학과 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  KSBB Journal

• 간기

  격월간

• pISSN

  1225-7117

• 수록기간

  2009~2013

• 십진분류

  KDC 476 DDC 576