Earticle

초록

영어

Ovulation resembles a tissue remodeling process such as a blood coagulation. The present study was aimed to examine the involvement of tissue factor, a primary factor for extrinsic coagulation pathway, in the ovulation. Northern blot analysis revealed that mRNA levels of tissue factor and tissue factor pathway inhibitor 2 (TFPI-2) in the ovary were stimulated by human chorionic gonadotropin (hCG) treatment in surperovulation model, of immature rats. Real-time PCR analysis demonstrated that the expression of tissue factor and TFPI-2 was stimulated in granulosa and theca cells of preovulatory follicles, respectively. The induction of tissue factor mRNA was blocked by the progesterone receptor antagonist RU486. Tissue factor protein was not detected in the ovary by Western blot and immunohistochemical analysis due to the lack of a specific antibody. Interestingly, the levels of tissue factor and TFPI-2 mRNA were increased in the ovarian cells of rats induced ovarian hyperstimulation syndrome (OHSS) and in granulosa cells of OHSS patients undergiong in vitro fertilization. The present findings indicate the stimulation of tissue factor system during ovulation, and in OHSS patients, implicating the possible involvement of tissue factor system in OHSS.

키워드

저자

• 김희경 [ 전남대학교 생물과학 · 생명기술학과, 전남대학교병원 의과대학 산부인과학교실 ]
• 박재일 [ 전남대학교 생물과학 · 생명기술학과, 전남대학교병원 의과대학 산부인과학교실 ]
• 전상영 [ 전남대학교 생물과학 · 생명기술학과, 전남대학교병원 의과대학 산부인과학교실 ]
• 조문경 [ 전남대학교 생물과학 · 생명기술학과, 전남대학교병원 의과대학 산부인과학교실 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  발생공학 국제심포지엄 및 학술대회 [International Symposium on Developmental Biotechnology]

• 간기

  연간

• 수록기간

  2004~2018

• 십진분류

  KDC 527 DDC 636