Polyphenols in green tea are biologically active and may interact with commonly-consumed over-the-counter (OTC) drugs in the body. In this study, modulation of cytotoxicity of polyphenon 60 (PPE, tea polyphenol mixture) with co-treatment of several OTC drugs, including ibuprofen (Ibu), acetaminophen (AAP), and aspirin was investigated in intestinal cells. PPE showed more potent cytotoxic effects on colon cancer HCT 116 cells than on normal intestinal INT 407 cells. Ibu had the strongest cytotoxic effects on both cell types. Cytotoxicity of PPE on HCT 116 and INT 407 cells was not markedly altered by co-treated OTC drugs. Cytotoxicity of the OTC drugs was not affected by PPE. When HCT 116 cells were incubated with AAP before or after PPE treatment, cytotoxicity was slightly enhanced more than their additive effect. The present study may provide basic information of possible toxicity due to interaction of the polyphenols and the OTC drugs.
목차
Abstract 서론 재료 및 방법 실험재료 및 세포주 폴리페놀과 일반 의약품 성분의 단독 또는 복합처리에 의한 세포독성 평가 H2O2생성량 측정 결과 분석 및 통계처리 결과 및 고찰 PPE 및 약물에 의한 세포 독성 PPE와 약물의 복합처리 시 세포독성 변화 H2O2조절에 의한 세포독성 변화 고농도 약물독성에 대한 PPE의 영향 처리순서 변화에 의한 세포독성 변화 요약 감사의 글 문헌
키워드
green teapolyphenolcytotoxicityintestinal cellover-the-counter drug