Earticle

초록

영어

Population pharmacokinetics for gentamicin were compared with 20 Korean patients (14 male and 6 female) and 25 Caucasian appendicitis patients (16 male and 9 female). Two to six blood specimens were collected from all patients at the following times : just before a regularly scheduled infusion and at 0.5 hour after the end of a 0.5 hour infusion.
Nonparametric expected maximum(NPEM) algorithm for population modeling was used. The estimated parameters were the elimination rate constant(K), the slope(KS) of the relationship between K versus creatinine clearance(Ccr), the apparent volume of distribution (V), the slope(VS) of the relationship between V versus weight, gentamicin clearance(CL) and the slope(CS) of the relationship between CL versus Ccr and the V. The output includes two marginal probability density function(PDF), means, medians, modes, variance, skewness, kurtosis, and CV%. The mean K(KS) were 0.402±0.129 hr-1 (0.00486±0.00197 [hr·mL/min/1.73 m2]-1) and 0.425±0.137 hr-1(0.00432±0.00168 [hr·mL/min/1.73 m2]-1) for Korean and Caucasian populations, respectively. The mean V(VS) were not different at 14.3±3.69 L(0.241±0.0511 L/kg) and 15.8±4.81 L (0.236±0.0531 L/kg) for Korean and Caucasian populations, respectively (P>0.2). The mean CL(CS) were 5.68±1.69 L/hr (0.0714±0.0222 L/kg[hr·mL/min/1.73 m2]) and 6.29±1.84 L/hr (0.0629±0.0189 L/kg[hr·mL/min/1.73 m2]) for Korean and Caucasian populations, respectively. There are no differences in gentamicin pharmacokinetics between Korean and Caucasian appendicitis patients.

목차

Abstract
 연구 방법
  환자 집단
  약물투여 및 혈액채취
  겐타마이신 분석
  NPEM 분석
  Bayesian 분석
  통계 처리
 연구 결과
  환자 집단과 혈중농도
  K와 V Parameterization
  KS와 VS Parameterization
  CL와 V Parameterization
  CS와 VS Parameterization
  Bayesian 분석
 고찰
 결론
 참고 문헌

키워드

저자

• 범진필 [ Jin Pil Burm | 조선간호대학 간호과 ] Correspondence

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615