Earticle

초록

영어

The family of bile acids belongs to a group of molecular species of acidic steroids with very peculiar biological characteristics. They are synthesized by the liver from cholesterol through several complementary pathways and secreted into small intestine for the participation in the digestion and absorption of fat. The bile acids are mostly confined to the territories of the so-called enterohepatic circulation, which includes the liver, the biliary tree, the intestine and the portal blood with which bile acids are returned to the liver. In patients with bile acid malabsorption, the amount of primary bile acids in the colon is increased compared to healthy controls. Although the increase in the secondary bile acids including deoxycholic acid, is reported to have the potency to affect tumorigenesis in gastrointestinal tracts, there is no firm evidence that clinically relevant concentrations of the bile acids induce cancer. The list of their physiological roles, as well as that of the pathological processes is long and still not complete. There is no doubt that many new concepts, pharmaceutical tools and pharmacological uses of bile acids and their derivatives will emerge in the near future.

목차

Abstract
 연구방법
  담즙산
  담즙산의 장간순환
  담즙산의 흡수장애
  담즙산의 체외 배출
  담즙산과 암
  담즙산과 암의 임상적 연관성
 결론
 참고문헌

키워드

저자

• 방준석 [ Joon Seok Bang | 가톨릭대학교 서울성모병원 ]
• 이유정 [ Yu Jeung Lee | 숙명여자대학교 임상약학대학원, 중앙대학교 의과대학 ]
• 정지훈 [ Ji Hoon Jeong | 중앙대학교 의과대학 ]
• 손의동 [ Uy Dong Sohn | 중앙대학교 약학대학 ] Correspondence

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615