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외래 환자에 있어 경구용 항혈전제(oral anti-thrombotics) 처방 양상의 분석 - 다품목 약제 사용 외래 처방전 중심으로 -
Analysis of prescribing patterns of oral anti-thrombotics in outpatients - Focusing on prescriptions containing multiple drugs -
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- 발행기관
- 한국보건사회약료경영학회 바로가기
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- 간행물
- 한국보건사회약료경영학회지 바로가기
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- 통권
- Volume2 Number1 (2010.06)바로가기
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- 페이지
- pp.21-29
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- 저자
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- 언어
- 한국어(KOR)
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- URL
- https://www.earticle.net/Article/A148352
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- The number of patients with cerebrovascular disease, cardiovascular disease and peripheral arterial disease has recently grown. Accordingly, the prescription of anti-thrombotic agents to prevent or treat those macrovascular diseases has been dramatically increased. The objectives of this study were to investigate the prescribing patterns of oral anti-thrombotic drugs in outpatients and assess the appropriate use of those drugs based on KFDA indications and DUR criteria. Out of 17, 376, 715, only 482 prescriptions were finally selected which they contained both multiple drugs and oral anti-thrombotics. The analysis of the selected prescriptions revealed that 43.4%, 36.0% and 29.0% were coded with cerebrovascular, cardiovascular and peripheral arterial disease, respectively. The average (±SD) number of oral anti-thrombotics per prescription was 1.51 (±0.70). Among the oral anti-thrombotic agents, aspirin (34.2%) was prescribed the most, followed by clopidogrel (23.4%), cilostazol (8.7%), sarpogrelate (8.2%), limaprost (5.9%), triflusal (4.2%), beraprost (4.1%), mesoglycan (3.8%), warfarin (3.3%), sulodexide (1.2%), sulfomucopolysaccharide (1.2%), ticlopidine (1.0%) and indobufen (0.7%), whereas dipyridamole was not prescribed at all. Monotherapy (59.5%) exceeded multiple therapy (40.5%) and the most common combination was aspirin plus clopidogrel. It was found that 27.4% of aspirin containing prescriptions did not have any responsible disease code, suggesting that aspirin was used for primary prevention. In case of limaprost, it was used even more for the treatment of spinal stenosis (69.8%) than peripheral arterial disease (30.2%). As a result of the prescription adjudication, 72.8% of total prescriptions were acknowledged to be appropriate, and the rate of inappropriate use was calculated as follows; sulodexide (78%), beraprost (67%), sarpogrelate (60%), ticlopidine (57%), cilostazol (46%), sulfomucopolysaccharide (44%), triflusal (41%), mesoglycan (39%), clopidogrel (36%), limaprost (23%), indobufen (20%), aspirin(1%) and warfarin (0%). Our findings indicated that aspirin was the most commonly prescribed oral anti-thrombotic agents for preventing or treating macrovascular diseases, and this prescribing patterns corroborated text books and clinical practice guidelines.
목차
Abstract
연구방법
1. 분석대상
2. 분석방법
연구결과
1) 일반적 특성
2) 치료군 또는 성분별 처방 양상 분석
3) 단독요법
4) 병용요법
5) Aspirin 처방 양상 분석
6) Limaprost 처방 양상 분석
7) 경구용 항혈전제 평균 성분 수
8) 약제 사용 적정성 평가
고찰
참고문헌
키워드
anti-thrombotic macrovascular disease aspirin anti-platelet anti-coagulant저자
간행물 정보
발행기관
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- 발행기관명
- 한국보건사회약료경영학회 [Korean Academy of Social & Managed Care Phemacy]
- 설립연도
- 2009
- 분야
- 의약학>약학
- 소개
- 본 학회는 비영리 학술단체로서 환자의 삶의 질 향상을 위한 약료(pharmaceutical care)가 보장될 수 있도록 약료경영약학(managed care pharmacy)을 발전시키는 데 궁극 목적을 두고 다음과 같은 활동을 전개하여 사회에 기여하며 회원 상호간의 친목을 도모한다.
간행물
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- 간행물명
- 한국보건사회약료경영학회지 [Journal of Korean Academy of Managed Care Pharmacy]
- 간기
- 반년간
- pISSN
- 2092-8394
- 수록기간
- 2009~2022
- 십진분류
- KDC 518 DDC 615
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