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신장이식 환자에서 발생되는 Cyclosporin에 의한 고요산혈증과 요산 패설 촉진제인 Benzbromarone의 효과
Cyclosporin-induced Hyperuricemia and the Uricosuric Efficacy of Benzbromarone in Kidney Transplant Patients

첫 페이지 보기
  • 발행기관
    한국임상약학회 바로가기
  • 간행물
    한국임상약학회지 바로가기
  • 통권
    제12권 제1호 (2002.03)바로가기
  • 페이지
    pp.13-21
  • 저자
    차문선, 오정미, 한덕종
  • 언어
    한국어(KOR)
  • URL
    https://www.earticle.net/Article/A1481

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원문정보

초록

영어
After the introduction of cyclosporin, the graft survival rate of renal transplant and patients' life expectancy have been greatly improved. However, cyclosporin is known to cause several undesirable side effects, one of which is hyperuricemia, which may subsequently cause gouty nephropathy and graft dysfunction. The purpose of this study was to evaluate the frequency and predisposing factors of hyperuricemia in cyclosporin-treated patients within one year of kidney transplantation and uricosuric efficacy of benzbromarone. The patients who were treated with cyclosporin after kidney transplantation in 1998 and the patients who were treated with benzbromarone for the control of cyclosporin-induced hyperuricemia in 1999 were investigated retrospectively. Among the 76 patients in cyclosporin-treated patients in 1998, hyperuricemia occurred in 55 patients and the mean time from kidney transplantation to occurrence of hyperuicemia was months. In 1999, 22 patients were treated with benzbromarone for hyperuricemia and their mean time from kidney transplantation to occurrence of hyperuricemia was months. Acute rejection developed in one patient out of 21 normo-uricemic patients and 11 patients out of 55 hyperuricemic patients in 1998. The difference of rejection rate in these two groups was significant (p<0.001). There was no difference of rejection rate between before and after treatment of benzbromarone. Cyclosporin trough levels did not show a significant correlation with the serum uric acid levels among the three groups. However, hyperuricemic patients showed significantly higher serum creatinine levels than patients with normal uric acid levels (p<0.001). Benzbromarone decreased serum uric acid levels from (p<0.0001) and normalizing serum uric acid in all of 22 patients. Except for one patient who experienced diarrhea, no significant side effect was noted.

키워드

Hyperuricemia Uric acid Cyclosporin Benzbromarone Kidney Transplantation

저자

  • 차문선
  • 오정미
  • 한덕종

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국임상약학회 [Korean College of Clinical Pharmacy]
  • 설립연도
    1
  • 분야
    의약학>약학
  • 소개
    합리적 약물치료(rational pharmacotherapy)의 보장 및 증진을 궁극목적으로 하며 이를 달성하기 위해 임상약학의 발전과 회원 상호간의 친목을 도모한다.

간행물

  • 간행물명
    한국임상약학회지 [Korean Journal of Clinical Pharmacy]
  • 간기
    계간
  • pISSN
    1226-6051
  • 수록기간
    1991~2026
  • 등재여부
    KCI 등재
  • 십진분류
    KDC 518 DDC 615

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