Earticle

초록

영어

Pharmacokinetic parameters and dosage of aminoglycosides (AGs) were studied retrospectively in 36 patients with neutropenic fever after stem cell transplantation in Seoul National University Hospital from July 1996 to June 2001. AGs pharmacokinetic parameters were calculated with steady-state peak and trough serum drug concentrations by the method of Sawchuk and Zaske et at. The calculated aminoglycosides volume of distribution and clearance were greater than population value . The average dosage of aminoglycosides required to maintain optimal serum AGs concentration was also greater than recommended dose in insert paper. The average dosage of amikacin was mg/kg every 12 hours (In case of tobramycin, mg/kg every 8 hours or mg/kg every 12 hours). The relationship between AGs volume of distribution and sex, serum albumin (g/dl), body mass index , body weight change , the amount of fluid inpu (ml/kg/day), the degree of hematocrit decrease were studied respectively. Univariate anlysis revealed that body mass index , the amount of fluid input (ml/kg/day) and the degree of hematocrit decrease had significant correlation with aminoglycosides volume of distribution. But sex, serum albumin, body weight change had no significant correlation with aminoglycosides volume of distribution.

저자

• 최미영
• 김민정
• 김호순
• 신완균
• 김귀숙
• 손인자

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615