Earticle

초록

영어

Bolus intravenous injection of adenosine resulted the temporal decrease of systemic blood pressure and heart rate in the anesthetized rats. Adenosine also resulted the persistent decrease of contractility and heart rate in the isolated spontaneously beating rat right atria. Both of the above inhibition effets of adenosine were increased by the pretreatment of NBI (nitrobenzylthioinosine), whitch is an adenosine transport inhibitor, but decreased by the pretreatment of 8- phenyltheophy1line, which is an adenosine antagonist. In isolated thoracic aorta ring segment of normotensive rats, intact rings were relaxed by adenosine (42.3±8.7%) and ATP (85.9±15.8%) in the concentration of 10-4 M, but rubbed rings were relaxed by adenosine (35.2±1.9%) and ATP (11.3±9.0%) in 10-4 M. After pretreatment of L-NAME (N-Nitro-Larginine methyl ester), which is an NO inhibitor, adenosine-induced relaxation was not affected, but ATP-induced relaxation was significantly inhibited (P<0.01). Meanwhile, adenosine resulted almost same as vasorelaxation in isolated thoracic aorta of SHR comparing to those of normotensive rats. But, vasodilation responses of ATP in intact rings of SHR are significantly inhibited comparing to those of normotensive rats. Adenosine-induced relaxation is attenuated after 8- phenyltheophylline pretreatment, but increased after NBI pretreatment. However, ATP-induced relaxations are not affected by 8-phenyltheophylline or NBI pretreatment. These results suggested that the hypotensive effects of adenosine was due to the decrease of contractile force and heart rate through the A1 receptor and vasodilation are mediated by A2 receptor of the vascular smooth muscle. And, the heart protective and vasodilation effects of adenosine might suggest that it would be useful in the acute treatment of coronary artery disease.

목차

Abstract
 실험방법
  시약 및 실험동물
  마취된 흰쥐에서의 혈압 및 심박수 변화
  적출 우심방에서의 수축력 및 심박수 변화
  적출 혈관반응 실험
  통계처리
 결과 및 고찰
  마취된 흰쥐에서의 혈압 및 심박수 변화
  적출 우심방에서의 수축력 및 심박수 변화
  흰쥐의 혈관반응
 결론
 참고문헌

키워드

저자

• 안형수 [ Hyung Soo Ann | 동덕여자대학교 약학대학 ] Correspondence
• 이영미 [ Young Me Lee | 동덕여자대학교 약학대학 ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국임상약학회지 [Korean Journal of Clinical Pharmacy]

• 간기

  계간

• pISSN

  1226-6051

• 수록기간

  1991~2026

• 등재여부

  KCI 등재

• 십진분류

  KDC 518 DDC 615