Earticle

초록

영어

In this study, 18 natural products were screened via anti-angiogenesis experiments, and 1 candidate product was identified, Siegesbeckiae herba, which exerted dose-dependent inhibitory effects against angiogenesis, adipogenesis, and cell adhesion. S. herba extract (SHE) exhibits an angiogenesis inhibitory effect superior to that of the EGCG from green tea leaves. The expression level of angiogenesis and adipogenesis-related signal molecules in the western blotting was reduced by increasing the amount of added SHE. Moreover, a diet supplemented with SHE was deemed more effective in inducing weight loss in LB mice than a representative synthetic diet drug, orlistat, which incidently caused the side effect of denuding the mice of their hair. These results indicate that S. herba may prove to be a useful anti-adipogenic compound, and these in vitro results may be reflected later under in vivo conditions.

키워드

저자

• Jong Deog KIM [ Department of Biotechnology, Research center on Anti-Obesity and Health Care, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea. ]
• Jin Hyuk SHIN [ Department of Biotechnology, 2Dept. of Culture Biotechnology Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea ]
• Hui Jin KIM [ Dept. of Culture Biotechnology Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea ]
• Go Woon CHAE [ Department of Biotechnology Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea ]
• Jae Ho HWANG [ Dept. of Culture Biotechnology Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea ]
• Hyo Jin SEO [ Department of Biotechnology Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea ]
• Kyeong Ho HAN [ Dept. of Culture Biotechnology, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea ]
• Min Yong KIM [ Dept. of Refrigeration Eng., Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea, Research center on Anti-Obesity and Health Care, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea. ]
• Tai Sun SHIN [ Dept. of Food Science and Nutrition, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea, Research center on Anti-Obesity and Health Care, Chonnam National University, San96-1, Dun-Duk Dong, Yosu, Chonnam, 550-749, Korea. ]
• Suk Jung OH [ ECOBIO INC, TBI center, Chonnam Univ, Yongbong-dong, Puk-gu, Gwangju ,500-757, Korea, ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576