Earticle

초록

영어

This study reports on a drug-eluting stent (DES) that has an anti-proliferation and an anti-coagulation in biodegradable polymer and nature polymer hydrogel-coated onto a cobalt-chromium stent. The DES was prepared by ultra-sonic spray coating the bare metal stent with PLGA loaded sirolimus and Alginate hydrogel loaded heparin top-coat to treat against restenosis and coagulation, respectively. The double-layered drug coated stent was characterized in vitro for surface morphology and coated thickness by scanning electron microscopy (SEM) and confocal microscopy. Additionally, the in vitro degradation and agents release study of the different cross-linking degree alginate hydrogel as CaCl2 concentration were examined. The results show DES can controlled release both anti-proliferation drug ( sirolimus ) and anti-coagulation agent ( heparin ). This result expect reduction restenosis because sirolimus control release. Sirolimus control release was reported of reduction restenosis as smooth muscle cell proliferation suppression.(1) Also, heparin control release was expect anti-activation of platelets and anti-coagulation. Heparin release or immobilization was reported of anti-thrombosis effect as improved blood compatibility. (2) Therefore, this study Alginate top-coated sirolimus-eluting stent will be expected provide effective coronary artery disease treatment. Acknowledgment : This study was supported by a grant of the Korea Healthcare technology R&D Project Ministry for Health, Welfare &Family Affairs, Republic of Korea. (A085012).

키워드

저자

• Jung Ho KIM [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentisty, Kyung Hee University, Seoul 130-701, Republic of Korea. ]
• Min Soo BAE [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentisty, Kyung Hee University, Seoul 130-701, Republic of Korea. ]
• Ho-Jin MOON [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentisty, Kyung Hee University, Seoul 130-701, Republic of Korea. ]
• Jae-Geun PARK [ Stent R&D institute of DIO corp. ]
• Soon Joong KIM [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentisty, Kyung Hee University, Seoul 130-701, Republic of Korea. ]
• Il Keun KWON [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentisty, Kyung Hee University, Seoul 130-701, Republic of Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576