Zanthoxylum is a genus of about 250 species of deciduous and evergreen trees and shrubs in the citrus or rue family, Rutaceae, native to warm temperature and subtropical areas worldwide. The genus Zanthoxylum has been credieted with a long list of ethnompharmacological properties. In the present study, in vitro anti-oxidant and anti-tyrosinase properties of extracts of Z. piperitum and Z. schinifolium leaves extracts were evaluated using various assays. Z. piperitum and Z. schinifolium leaves harvested at the mature green stage were collected at Baek-un Mt. Chollanam-do, S. Korea in August 2009. The extracts of Z. piperitum and Z. schinifolium leaves using methanol, n-hexane, chloroform, ethy acetate or butanol as solvents were evaluated for their tyrosinase inhibition, anti-oxidant and anti-microbial properties. The anti-tyrosinase and anti-oxidant potentials were determined by in vitro mushroom tyrosinase assay and the free radical scaening activity methods. Both of these results showed the strong inhibition abilities at a dosage of 100.0 ug/ml. Particularly, higher activity was exhibited by Z. piperitum with 92.8% and 80.1% inhibition of butanol and ethyl acetate extracts, while 78.2% and 57.8% inhibitions by Z. schinifolium respectively. However, both butanol extracts exhibited higher DPPH radical scavening activity than the corresponding methanol, n-hexane, chloroform, and ethyl acetate extracts. In addition, extracts of Z. piperitum leaves showed more potent anti-tyrosinase activity than Z. schinifolium leaves. Anti-microbial activities against Gram(+) and Gram(-) bacteria demonstrated good inhibition at 34.8 –43.6 ug/ml. These results obtained from biological assays showed that extracts of Z. piperitum and Z. schinifolium leaves possessed multiple bioactivities, including anti-tyrosinase, anti-oxidants, anti-microorganism and cell proliferation. The data exhibited the high potential of applying extracts of Z. piperitum and Z. schinifolium leaves in cosmoceutical lines.
키워드
AntioxidantstyrosinaseZ. PiperitumZ. Schinifolium
저자
Sung Jin HWANG [ Dept. of Biology, Coll. of Natural Sci., Chonnam Nat'l Univ., Gwang-ju 500-757. ]
Sang Mi HAN [ National Inst. of Agri. Sci. &Technol., RDA, Suwon 441-400, S. Korea. ]
Suk Cheon PAK [ School of Biomedical Sciences, Charles Sturt University, Bat, Australia. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회