Earticle

초록

영어

We report on the development of an efficient optical-sensing platform for the detection of toxic organophosphates using self-assembled peptide nanotubes. Diphenylalanine (Phe-Phe, FF), found in the key motif of Alzheimer’ b-amyloid, was used as a building block to create self-assembled nanotubes that became highly photoluminescent through in-situ incorporation of lanthanide complexes such as salicylic acid/terbium ions or 1,10- phenanthroline/europium ions during the self-assembly process. We found that photoluminescent FF nanotubes underwent a drastic quenching of their emission within a few seconds upon exposure to paraoxon, a nitrofunctionalized neurotoxin. The photoluminescence quenching occurred due to the interruption of cascaded-energy transfer from FF nanotubes to lanthanide ions. The assay platform provided high selectivity toward paraoxon among other organophosphates (e.g., diethylchlorophosphate, dichlorvos, malathion, phosmat), nitro-group compounds (e.g., nitromethane, nitrobenzene, 4-nitrophenol) and common organic chemicals (e.g., alcohols, ethers, ketones, etc.), capability of which was attributed to the role of the FF nanotubes as a host matrix for lanthanide complexes. The peptide nanotube-based optical sensor hints at an alternative route for the selective detection of neurotoxins while avoiding low selectivity, slow response time, and instability of biological receptors in other biosensors.

키워드

저자

• Jae Hong KIM [ Dept. of Materials Science and Engineering, KAIST, Daejeon, 305-701. ]
• Jungki RYU [ Dept. of Materials Science and Engineering, KAIST, Daejeon, 305-701. ]
• Chan Beum PARK [ Dept. of Materials Science and Engineering, KAIST, Daejeon, 305-701. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576