Exess ethanol intake is usually toxic in health. Chronic ethanol consumption causes oxidative damage in liver. Acer tegmentosum MAX. good for a liver has been known since ancient times in Korea and China. Ethanol-induced oxidative stress is related to the metabolism of ethanol. The major part of the ethanol is metabolized by alcohol dehydrogenase in liver. Alcohol dehydrogenase to form acetaldehyde results in the formation of free radicals. Cytochrome P450 2E1 (CYP2E1) participates to the ethanol decomposition. Excess ethanol intake affects more microsomal enzyme CYP2E1 activity than ADH resulting in causing oxidant stress. CYP2E1 has been to be a major contributor to ethanol-induced oxidant stress. Thereby, decrease of SOD, CAT, GSH. In this study, we investigated in vitro and in vivo the inhibition of ethanol-induced liver injury by Acer tegmentosum MAX. extract. In vitro studies with ROS scavenging, decreased of CYP2E1, and increased of SOD, CAT, GSH showed that verification antioxidant activity. In vivo studies, SD Rats were treated by ethanol administration. SD Rats were injected with or without ethanol (35% ethanol, 10ml/kg per day) and Acer tegmentosum MAX. extract (120mg/kg per day) continuously for 5 week. In consequence, Acer tegmentosum MAX. extract was recognized to inhibit the liver maker emzymes (AST, ALT, GGT) and increased of SOD, CAT, GSH.
키워드
LIVER INJURYAcer tegmentosum MAXCYP2E1
저자
JUNG WOON PAHK [ Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea. ]
EOCK-KEE HONG [ Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회