Sungjun YOON, Jeong Ah KIM, Min Seok KANG, Tai Hyun PARK
언어
영어(ENG)
URL
https://www.earticle.net/Article/A145025
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Magnetic field (MF) therapy is an emerging method of treatment for numerous neurodegenerative diseases. However, the exact mechanism of how and to what degree a magnetic field affects neurological function remains controversial. In Alzheimer’ disease, hyperphosphorylation of tau protein is known as one of the main causes of neurofibilary tangles leading to neuronal death. In this study, effects of a range of static magnetic fields (SMF) and electromagnetic fields (EMF) on phosphorylation of tau protein have been investigated. PC12 cells treated with nerve growth factor (NGF) have been exposed to SMF of 3 mT, 15 mT, and 170 mT and an EMF of 1 mT at 50 Hz for 4 days. Tau protein phosphorylation level of each sample was examined, and the results indicated that the phosphorylation level increased with low MF exposures (1, 3 mT) and decreased with high MF exposures (15, 170 mT) when compared with the control. To examine more specifically where this effect takes place, expression levels of some of the upstream genes related to tau phosphorylation have been observed. This study suggests that MF may open up a new venue for the treatment of Alzheimer’ disease.
키워드
Alzheimer's DiseaseTau ProteinPhosphorylationMagnetic Field
저자
Sungjun YOON [ Interdisciplinary Program for Bioengineering, Seoul National University, Seoul 151-744. ]
Jeong Ah KIM [ School of Chemical & Biological Engineering, Seoul National University, Seoul 151-742. ]
Min Seok KANG [ School of Chemical & Biological Engineering, Seoul National University, Seoul 151-742. ]
Tai Hyun PARK [ School of Chemical & Biological Engineering, Seoul National University, Seoul 151-742. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회