Su-Jung KIM, Joon-Serk SEO, Sun-Mi YOO, Kyung-Ho KANG, Eun-Sun KO, Sang-Min LIM, Dong-Il KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A145016
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Type 1 diabetes (T1D) has been known as a disease caused by T cell-mediated autoimmune destruction of pancreatic cells. Generation of insulin-producing cells (IPCs) from various kinds of stem cells have immense potential for the treatment of T1D due to the shortage of pancreas donors. Mesenchymal stem cells (MSCs) are uniquely capable of crossing germinative layers borders. Moreover, MSCs are obtainable in high numbers via ex vivo culture. Many researchers have therefore searched for diverse sources of MSCs, such as bone marrow, Wharton's Jelly, adipose tissue, and periosteum. In this study, we compared the growth potency of three kinds of MSCs derived from different tissues. In addition, in vitro differentiation of those MSCs into IPCs was also investigated. Induced IPCs was confirmed by using immunofluorescence. ELISA was used to measure the level of insulin. By using RT-qPCR, expression levels of insulin genes were detected. It was found that the periosteum-derived progenitor cells (PDPCs) have a potential as a source for the differentiation into IPCs.
키워드
Type 1 diabetesMesenchymal stem cellsinsulin-producing cellsperisteum-derived progenitor cells
저자
Su-Jung KIM [ Department of Biological Engineering, Inha University, Incheon, Korea. ]
Joon-Serk SEO [ Department of Biological Engineering, Inha University, Incheon, Korea. ]
Sun-Mi YOO [ Department of Biological Engineering, Inha University, Incheon, Korea. ]
Kyung-Ho KANG [ Department of Biological Engineering, Inha University, Incheon, Korea. ]
Eun-Sun KO [ Department of Biological Engineering, Inha University, Incheon, Korea. ]
Sang-Min LIM [ Department of Biological Engineering, Inha University, Incheon, Korea. ]
Dong-Il KIM [ Department of Biological Engineering, Inha University, Incheon, Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회