Earticle

초록

영어

Microfracture of cartilage induces migration of bone marrow-derived mesenchymal stem cells (BMMSCs). However, this treatment often results in fibrocartilage regeneration. Bone morphogenetic protein (BMP)-2 induce the differentiation of BMMSCs into chondrocytes, which can be used for hyaline cartilage regeneration. We tested the hypothesis that long-term delivery of BMP-2 to cartilage defects subjected to microfracture results in regeneration of high quality hyaline-like cartilage. Heparin-conjugated fibrin (HCF) and normal fibrin were used as carriers for the long and short-term delivery of BMP-2, respectively. Rabbit articular cartilage defects were treated with microfracture combined with one of the following: no treatment, fibrin, short-term delivery of BMP-2, HCF or long-term delivery of BMP-2. Eight weeks after treatment, histological analysis and biochemical assay revealed that the long-term delivery of BMP-2 group had the highest GAG content and expression level of collagen type II. Taken together, the long-term delivery of BMP-2 to cartilage defects subjected to microfracture resulted in regeneration of hyaline-like cartilage.

키워드

저자

• Hyeon-Ki JANG [ Interdisciplinary program of Bioengineering, Seoul National University, Seoul. ]
• Hee Seok YANG [ Department of Bioengineering, Hanyang University, Seoul, 133-791. ]
• Wan-Geun LA [ School of Chemical and Biological Engineering, Seoul National University, Seoul. ]
• Suk Ho BHANG [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744. ]
• Hak-Jun KIM [ Department of Orthopaedic Surgery, Ansan Hospital, College of Medicine, Korea University, Ansan. ]
• Jung-Ho PARK [ Department of Orthopaedic Surgery, Ansan Hospital, College of Medicine, Korea University, Ansan, 425-020. ]
• Byung-Soo KIM [ Interdisciplinary Program of Bioengineering, Seoul National University, Seoul, 151-744. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576