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The influence of Laminin-derived Peptides conjugated to Thermoplastic Polycarbonate Urethane on Neural Cell Adhesion

첫 페이지 보기
  • 발행기관
    한국생물공학회 바로가기
  • 간행물
    한국생물공학회 학술대회 바로가기
  • 통권
    2011년도 한국생물공학회 춘계학술발표대회 (2011.04)바로가기
  • 페이지
    pp.240-240
  • 저자
    Ha Na PARK, Jung Bok LEE, Dong Nyung HEO, Dae Hyeok YANG, Il Keun KWON
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A144998

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원문정보

초록

영어
YIGSR (Tyr-Ile-Gly-Ser-Arg) and IKVAV (Ile-Lys-Val-Ala-Val), which are located in the β1 and α1 chain of laminin, have been demonstrated to promote cell adhesion and growth.[1] A thermoplastic polycarbonate urethane (TPU) is attractive in biomedical applications due to its outstanding physical properties, biostability, and biocompatibility.[2] In this study, we evaluated the effect of the YIGSR/IKVAV surface-conjugated two different morphogic TPUs for their specificity and growth promotability using nerve cell. Two morphologies of TPU substrates, film (MTPU) and aligned fiber (STPU), were prepared by solvent casting and electrospinning methods, respectively. To conjugate the peptides on the surface of TPUs, the substrates were activated by oxygen plasma treatment, and then poly(ethylene glycol) bisamine (PEG-BA) was grafted on the surface as a linker between the TPUs and the peptides. The resulting TPU surfaces were characterized by ATR-FTIR spectra, water contact angle measurement, and XPS. Protein adsorption experiment was carried out to evaluate the protein-resistance of the surfaces. The rate of protein adsorption was significantly reduced after modification. In addition, substrates were shown that have different influence on the nerve cell. The result was may occurred from different chain derivation. These laminin conjugated TPUs are expected that can use for dissimilar aimed neural engineering by means of distinctive interaction. Acknowledgement: This research was supported by the Pioneer Research Center Program through the National Research Foundation of Korea funded by the Ministry of Education, Science and Technology (2010-0019346).

키워드

nerve regeneration thermoplastic polycarbonate urethane peptide nerve cell adhesion

저자

  • Ha Na PARK [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea. ]
  • Jung Bok LEE [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea. ]
  • Dong Nyung HEO [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea. ]
  • Dae Hyeok YANG [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea. ]
  • Il Keun KWON [ Department of Maxillofacial Biomedical Engineering and Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, Republic of Korea. ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
  • 설립연도
    1984
  • 분야
    공학>생물공학
  • 소개
    이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동

간행물

  • 간행물명
    한국생물공학회 학술대회
  • 간기
    반년간
  • 수록기간
    1985~2013
  • 십진분류
    KDC 476 DDC 576

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