Earticle

초록

영어

To accomplish the therapeutic purpose in neural regenerative medicine using stem cells, control of both efficient differentiation into a target tissue and the axon guidance to desired direction are important. Herein, we used multi-walled carbon nanotube (mwCNT) sheets with aligned orientation to differentiate human mesenchymal stem cells (hMSC) into neuronal cells. Human MSCs were attached to aligned CNT sheets with longitudinal stretch in parallel direction to the CNTs. Elongation magnitude of cells was two-folds of the control and most of the cells aligned in sheet-CNT were within 5° angle of the CNT direction. Moreover, a significant synergistic effect on neuronal differentiation and cell adhesion was observed in hMSCs cultured on the CNT sheets. Axon outgrowth was also guided by the CNT pattern. This CNT sheet provides a new biomimetic platform that can regulate morphogenesis and differentiation of stem cells, which would open up the opportunities for tissue repair and regeneration of stem cell therapy.

키워드

저자

• Jeong Ah KIM [ School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744. ]
• Eui Yun JANG [ School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744. ]
• Yong Hyup KIM [ School of Mechanical and Aerospace Engineering, Seoul National University, Seoul 151-744. ]
• Tai Hyun PARK [ School of Chemical and Biological Engineering, Seoul National University, Seoul 151-744. ]

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발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576