Kyung-baeg ROH, Jienny LEE, Young-soo KIM, Jongsung LEE, Deokhoon PARK
언어
영어(ENG)
URL
https://www.earticle.net/Article/A144808
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Edible bird's nest (EBN), made from the salivary excretions of the swiftlet, is one of the widely used health foods in asian communities. Until now, although EBN has been known to have immune-boosting and anti-viral activities, other functions have not been reported. This study is aimed to investigate the effects of EBN on proliferation of human adipose-derived stem cells (hADSCs) and its action mechanism. We found that EBN strongly promoted proliferation of hADSCs and nomal human fibroblasts (NHFs). Additionally, attempts to elucidate a possible mechanism underlying the EBN-mediated effects reveald that EBN induced production of IL-6 and VEGF, and that this was mediated through activation of NF-kB. Specially, WE found that production of IL-6 and VEGF was induced by EBN. In addition, EBN-induced production of IL-6 and VEGF was inhibited by PD98059, a p44/42 MAPK inhibitors, SB203580, a p38 MAPK inhibitor, and PDTC, a NF-kB inhibitor, but not SP600125, a JNK inhibitor. Similar to this, EBN-induced proliferation of hADSCs was also attenuated by PD98059, SB203580 and PDTC, but not SP600125. Taken together, these findings suggest that the EBN-induced proliferation of hADSCs primarily occurs through the increased expression of IL-6 and VEGF, which is mediated by the activation of NF-kB.
키워드
Edible bird nestProliferationADSCsMAPK
저자
Kyung-baeg ROH [ Biospectrum Life Science Institute. ]
Jienny LEE [ Biospectrum Life Science Institute. ]
Young-soo KIM [ Biospectrum Life Science Institute. ]
Jongsung LEE [ Biospectrum Life Science Institute. ]
Deokhoon PARK [ Biospectrum Life Science Institute. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회