Earticle

초록

영어

The purpose of this study was to investigate the protective effect of fermented Cham-Dang-Gui (Angelica gigas Nakai)(CDG) with Monascus purpureus strain on Orotic acid(OA)-induced fatty liver in rats. OA-feeding Sprague-Dawley rats were fed diets containing Cham-Dang-Gui (Angelica gigas Nakai)(CDG) and Fermented CDG at the 5%(w/w) levels for 10 days. OA administration resulted in significantly increase in the activities of the liver marker enzymes, aspartate amino transferase(AST), γ-glutamyl transpeptidase(γ-GTP), and lactate dehydrogenase(LDH) relative to the normal rats. Administration of Fermented CDG markedly prevented OA-induced elevation of the activities of serum AST, γ-GTP and LDH, and the levels of blood and these reduced levels reached to that of the normal rats. Fermented CDG treatment improved the antioxidant status of OA-induced fatty liver, which is evaluated by the decreased levels of lipid peroxidative index and increased levels of antioxidant status in the liver and serum. OA treatment induced the marked accumulation of large lipid droplets and resulted in typical histopathology of OA-induced fatty liver, but Fermented CDG attenuated lipid droplet accumulation in hepatocytes. These results suggested that Fermented CDG prevents OA-induced hepatotoxicity and oxidative stress, which is probably related to the reduction of hepatic marker enzymes activities and its antioxidant substance.

목차

Angelica gigas Nakai, Orotic Acid, Ferment

저자

• Hee-Young AHN [ Dept. of Medical Biosciences, Graduate School, Dong-A University, Busan 604-714. ]
• Su-Jin HEO [ Dept. of Medical Biosciences, Graduate School, Dong-A University, Busan 604-714. ]
• Jae-Hong LEE [ Dept. of Medical Biosciences, Graduate School, Dong-A University, Busan 604-714. ]
• Min-Jeong KANG [ Dept. of Medical Biosciences, Graduate School, Dong-A University, Busan 604-714. ]
• Kyu-Rim PARK [ Dept. of Biotechnology, Dong-A University, Busan 604-714. ]
• Young-Su CHO [ Dept. of Biotechnology, Dong-A University, Busan 604-714. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576