Su-Jin HEO, Hee-Young AHN, Min-Jeong KANG, Jae-Hong LEE, Sung-Su PARK, Young-Su CHO
언어
영어(ENG)
URL
https://www.earticle.net/Article/A144788
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
This study is aimed to evaluate the protective effect of Cordycepin-increased Cordyceps militaris(CM) strain on the triglyceride metabolism in orotic acid (OA)-fed rats was investigated. Male Sprague-Dawley rats were randomly divided into six groups (n=6) based on five dietary categories: Normal, OA control, OA plus Paecilomyces japonica (PJ)(3%,w/w), OA plus Cordyceps militaris (CM)(3%,w/w), OA plus Cordycepin- increased CM(3%,w/w). The activities of liver marker enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and the levels of lipid peroxidation were increased when OA was treated but these parameters were significantly decreased by Cordycepin-increased CM. OA treatment exhibited decrease in serum concentrations of triglyceride, total cholesterol, HDL-cholesterol and free fatty acids and these were also decreased by Cordycepin-increased CM. The current study observed significant elevations of the thiobarbituric acid-reactive substances (TBARS) levels. However, among the OA, Cordycepin-increased CM was significantly lowered in the TBARS levels of hepatic homogenate. OA resulted in a significant decrease in the levels of plasma and hepatic glutathione, but these reductions were significantly increased by Cordycepin-increased CM. Accordingly, Cordycepin-increased CM bean ideal can did ate for the hepatoprotective effect in animal model.
키워드
Cordyceps militarisOrotic AcidHepatoprotective
저자
Su-Jin HEO [ Dept. of Medical Biosciences, Graduate School, Dong-A University, Busan, 604-714. ]
Hee-Young AHN [ Dept. of Medical Biosciences, Graduate School, Dong-A University, Busan, 604-714. ]
Min-Jeong KANG [ Dept. of Medical Biosciences, Graduate School, Dong-A University, Busan, 604-714. ]
Jae-Hong LEE [ Dept. of Medical Biosciences, Graduate School, Dong-A University, Busan, 604-714. ]
Sung-Su PARK [ Dept. of Biotechnology,Dong-A University, Busan, 604-714. ]
Young-Su CHO [ Dept. of Biotechnology,Dong-A University, Busan, 604-714. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회