Earticle

초록

영어

The emergence of antibiotic-resistant pathogens has rekindled interest toward the discovery of new antibiotics. Semi-synthetic or biosynthetic approach using microbe as a biocatalyst can be an efficient tool for the targeted modification of existing antibiotic chemical scaffolds to create the next generation of antibiotics as well as previously uncharacterized therapeutic agents. An attempt was made to expand the applicability of the unique bio-hydrogenation activity of Streptomyces venezuelae toward other unsaturated macrolide antibiotics (natural oligomycin A and semisynthetic tilmicosin) that possess the above mentioned identical catalytic scaffold, and the structure and antibiotic potential of two previously uncharacterized macrolides, 2,3-dihydro-oligomycin A and 10,11-dihydro-tilmicosin, isolated from a S. venezuelae culture supplemented with oligomycin A and tilmicosin, respectively, were evaluated.

키워드

저자

• Eun Ji KIM [ Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea. ]
• Je Won PARK [ Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea. ]
• Eunji KIM [ Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea. ]
• Eun Young AHN [ Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea. ]
• Yeo Joon YOON [ Department of Chemistry and Nano Science, Ewha Womans University, Seoul, Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576