Byul-Nim AHN, Jung-Ae KIM, Chang-Suk KONG, Youngwan SEO, Se-Kwon KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A144535
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
영어
Corydalis heterocarpa, a kind of salt-tolerant plant, has been employed as folk medicine to cure travail and spasm, and some studies have reported the antioxidant and anti-inflammatory activities of components isolated from Corydalis heterocarpa. However, whether compound isolated from this plant attenuates the UVB-induced cell damage in skin still remains largely unknown. Solar ultraviolet (UV) radiation, particularly the UVB (290-320 nm) radiation causes various harmful biological effects including sunburn, melanoma and photoaging. This stud focused on the investigation of anti-photodamage effects of compound isolated from corydalis heterocarpa on UVB induced human keratinocyte (HaCaT) cells. The presence of compound in UVB-exposed keratinocytes suppressed the reactive oxygen species (ROS) generation and DNA damage. In addition, the compound down regulated the increased MMP-2, MMP-9 and up regulated the reduced TIMP-1, TIMP-2 protein and gene expressions due to UVB exposure. Furthermore, the under lying signaling mechanisms of UVB protective effects of compound was elucidated through ASK1-MAPK-responsive signaling pathways.
키워드
UVB irradiationKeratinocyteMAPK
저자
Byul-Nim AHN [ Dept. of Chemistry, Pukyoung National University, Busan 608-737. ]
Jung-Ae KIM [ Dept. of Chemistry, Pukyoung National University, Busan 608-737. ]
Chang-Suk KONG [ Department of Food and Nutrition, College of Medical and Life Science, Silla University, Busan 617-736. ]
Youngwan SEO [ Division of Marine Environment and Bioscience, Korea Maritime University, Busan 606-791. ]
Se-Kwon KIM [ Department of Chemistry and Marine Bioprocess Research Center, Pukyoung National University, Busan 608-737. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회