Jooyeon PARK, Hee Seok YANG, Wan Geun LA, Byung-Soo KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A144532
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원문정보
초록
영어
Biodegradable polymer/ceramic composite scaffolds for bone regeneration applications are advantageous over either biodegradable polymer or ceramic alone. In this study, a simple and fast method for fabricating a polymer/bioceramic composite scaffold by coating polydopamine (PD) to induce hydroxyapatite (HA) adsorption on polyglycolic acid (PGA) surfaces was developed. PGA meshes were coated with HA by immersing the scaffolds in a solution containing PD and HA for various periods of time. HA coating was examined by selective staining of ceramic particles, scanning electron microscopy, attenuated total reflectance Fourier transformed-infrared spectroscopy, X-ray photoelectron spectroscopy, and energy-dispersive spectroscopy. Substantial HA adsorption on PGA was achieved within 24 hours of incubation. To evaluate bone formation efficacy of scaffolds in vivo, PGA, PD-coated PGA, and HA/PD-coated PGA scaffolds were implanted to critical size defects in mouse skulls for 8 weeks. Soft X-ray radiography, microcomputed tomography and histological analyses showed that PD-induced HA-polymer scaffolds exhibited enhanced bone formation efficacy as compared to the polymer scaffolds.
키워드
Bone regenerationHydroxyapatite compositepolydopamine
저자
Jooyeon PARK [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744 ]
Hee Seok YANG [ Department of Bioengineering, Hanyang University, Seoul, 133-791. ]
Wan Geun LA [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, ]
Byung-Soo KIM [ School of Chemical and Biological Engineering, Seoul National University, Seoul, 151-744, ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회