Owing to their biodegradability, biocompatibility and low toxicity, various biomaterials using chitosan and their derivatives have been developed, especially in biomedical applications [1, 2]. Among these, hollow spheres have attracted increasing interest as drug delivery systems since they enable high loading of hydrophilic, hydrophobic or even solid-type drugs [3]. The formation of hollow microspheres generally involves the use of organic solvent and high temperature or high pressure, which is harmful to the biological environment. In the present study, chitosan hollow hydrogels were simply prepared by ionotropic gelation of chitosan with sodium tripolyphosphate. The fabrication process and major parameters were discussed and optimized. The morphological characteristics and formation mechanisms were characterized by scanning electron microscopy and paraffin section analysis. The results revealed that the microspheres exhibited a very smooth and hollow structure. Also, the formation of the hollow inside microspheres could be controlled by varying fabrication conditions including types of chitosan, concentrations and pH of sodium tripolyphosphate. This method of production of hollow spheres can be considered a simple, fast but effective preparation procedure of hollow hydrogel-based devices in biomedical applications.
키워드
sodium tripolyphosphatechitosanhollow hydrogel
저자
Thi Phuong Thuy PHAM [ Department of Bioprocess Engineering, Chonbuk National University, Jeonbuk, 561-756. ]
Sung Wook WON [ Department of BIN Fusion Technology, Chonbuk National University, Jeonbuk, 561-756 and Harvard-MIT's Division of Health Science & Technology. ]
Myung-Hee SONG [ Division of Semiconductor and Chemical Engineering, Chonbuk National University, Jeonbuk, 561-756. ]
Yeoung-Sang YUN [ Division of Semiconductor and Chemical Engineering, Department of Bioprocess Engineering and Department of BIN Fusion Technology, Chonbuk National University, Jeonbuk, 561-756. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회