In the last decade, advances in cancer research have enhanced our understanding of cancer biology and genetics. Anticancer effects may be exhibited through selective cytotoxicity, antiproliferative action, and apoptosis. Natural products or phytochemicals, substances found in edible fruits and vegetables, exhibit a potential for modulating human metabolism in a manner favorable for the prevention of chronic and degenerative diseases. Many different sub-tropical fruits are currently being evaluated for their effects against cancer as well as the possible mechanism of this action using various human cancer cell lines in our groups. The chloroform fraction (CF) of dangyuja leaf extract strongly decreased the survival rate of HeLa cells, whereas the CF of guava leaf extract exhibited the maximum cytotoxicity on SNU-16 cells. Both CF treatments induced the down-regulation of anti-apoptotic Bcl-2 expression, resulting in the proteolytic activation of caspases and the degradation of poly (ADP–ibose) polymerase (PARP) protein in these cell lines. Arrested cell growth and induction of apoptosis were confirmed by flow cytometry and DNA fragmentation analysis, respectively. The major components, which might be responsible for induction of apoptosis, of two different CFs identified by high performance liquid chromatography coupled with photo diode array and electrospray ionization mass spectrometry (HPLC-PDA-ESI-MS) will be discussed.
저자
Somi Kim CHO [ Faculty of Biotechnology, Subtropical Horticulture Research Institute, Jeju National university Jeju, 690-756, South Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
간행물명
한국생물공학회 학술대회
간기
반년간
수록기간
1985~2013
십진분류
KDC 476DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2011년도 한국생물공학회 춘계학술발표대회