Earticle

초록

영어

The methods currently used for treating alopecia have some limitations. The number of hair transplantation restricts because total transplantable hair number is no increase. To overcome these problems, researchers have attempted the in vitro culturing of hair follicle cells and implanting these cells in the treatment area. In the present study, culture-expanded mesenchymal stem cells (MSCs) that do not possess aggregative activity were used to produce self-aggregated cell-aggregated spheroidal dermal papilla like tissues (DPLTs) with the aid of a special culture condition in vitro, and hair bulb structure inductive capacity pertinent to the aggregative activity was then evaluated. Then hair inducing activity of self-aggregated DPLTs employing MSCs was tested in athymic mice.The DPLTs have the same hair bulb structure inductive ability as natural DPLTs in vitro. Transplanted DPLTs can induce new hair follicle in athymic mice. As a result, UC-MSCs and BM-MSCs may be an applicable and novel cell sources for the generation of human hair cell therapy.

저자

• Jung-Keug Park [ Departments of Medical Biotechnology, Dongguk, University Seoul, Korea. Dongguk University of Research Institute of Biotechnology (DURIB), Seoul, Korea. ]
• Bo-Young Yoo [ Dongguk University of Research Institute of Biotechnology (DURIB), Seoul, Korea. ]
• Hee-Hoon, Yoon [ Dongguk University of Research Institute of Biotechnology (DURIB), Seoul, Korea. ]
• Kye-Yong Song [ Department of Pathology, Chung-Ang University College of Medicine, Seoul, Korea. ]

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간행물

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• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576