Earticle

초록

영어

The solvent treatment of paclitaxel is a convenient method for controlling the morphologies of paclitaxel. Amorphous paclitaxel was simply made by dissolving paclitaxel in methylene chloride/methanol (98/2, v/v) and inrelatively non-polar solvents (t-butyl methyl ether, pentane, acetonitrile/hexane (1/2, v/v), methylene chloride, chloroform, toluene). On the other hand, crystalline paclitaxel was made by dissolving paclitaxel in a special polar solvent containing a small amount of water. Thus, polarity of the solvent was an important factor governing the morphology of the paclitaxel. Their physicochemical properties were investigated by X-ray powder diffraction (XRPD), scanning electron microscopy (SEM), and high performance liquid chromatography (HPLC). The initial water content of amorphous paclitaxel and crystalline paclitaxel was determined for 0.65 wt% and 5.85wt%, respectively. The hygroscopic property of crystalline paclitaxel was very changeable in all given humidity (15, 60, 95 RH%) during storage. Dissolution profiles for paclitaxel showed that amorphous paclitaxel measured the highest solubility in water and its solubility held most stable during the measurements. The residual solvent could be reduced to the maximum allowed value (600 ppm for methylene chloride, 3,000 ppm for methanol) of guidance for the International Conference on Harmonization (ICH) by spray drying.

키워드

저자

• Jae-won YOON [ Department of Chemical Engineering, Kongju National University, Cheonan, 330-717. ]
• Min-Gyeong HAN [ Department of Chemical Engineering, Kongju National University, Cheonan, 330-717. ]
• Ji-Yeon LEE [ Department of Chemical Engineering, Kongju National University, Cheonan, 330-717. ]
• Jin-Hyun KIM [ Department of Chemical Engineering, Kongju National University, Cheonan, 330-717. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576