Earticle

초록

영어

The PGSS (Particles from Gas Saturated Solutions) process is a promising technique that uses supercritical fluid to produce fine particles under relatively mild operating conditions. In this technique, a supercritical fluid is dissolved into a solution or a melted material.
Under the appropriate pressure and temperature conditions, this mixture is rapidly depressurized through a nozzle, resulting in the formation of fine solid particles. Gemcitabine is a pyrimidine nucleoside analogue with a high antitumor efficacy for the treatment of ovarian, breast, bladder, and pancreatic cancers. In this study, gemcitabine-loaded polymer particles were parepared using a PGSS technique. The effect of temperature, pressure, the type of biodegradable polymers, and micronization of gemcitabine using a supercritical ASES (Aerosol Solvent Extraction System) process on the morphology and drug entrapment efficiency of PGSS-processed particles were investigated.
The entrapment efficiency of gemcitabine from particles was also determined using HPLC assay.

키워드

저자

• Byung-Hyun WON [ Dept. of Chemical Engineering, The University of Suwon, Gyeonggi-do, Korea. ]
• In-Il JUNG [ Dept. of Chemical Engineering, Yonsei University, Seoul, Korea. ]
• Gio-Bin LIM [ Dept. of Chemical Engineering, The University of Suwon, Gyeonggi-do, Korea. ]
• Jong-Hoon RYU [ Dept. of Chemical Engineering, The University of Suwon, Gyeonggi-do, Korea. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576