Eicosapentaenoic acid(EPA) in one of omega-3 fatty acids in unsaturated fatty acids and plays a pivotal role in protection against oxidative damage-related diseases due to anti-inflammatory effects.In this study, anti-inflammatory effects of EPA loaded nano-particles(ENP) on lipopolysaccharide(LPS)-induced murine macrophage cells (RAW264.7) were investigated. The nanoparticles released EPA which was able to inhibit the production of nitric oxide (NO) by suppressing the expression of inducible nitric oxide synthase (iNOS) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophage cells. NO production and iNOS expression was significantly decreased in dose-dependent manner when cells were treated with various concentrations of ENP.
키워드
Eicosapentaenoic acidRAW 264.7Macrophages
저자
Jin KIM [ Department of Advanced Chemicals and Engineering, Chonnam Nat. Univ., KOREA. ]
Dong-Woon KIM [ Department of Clinical Pathology, Gwangyang Health College., KOREA. ]
Ki-Young LEE [ Faculty of Applied Chemical Engineering, and Institute for Catalysis Chonnam Nat. Univ., KOREA. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
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