Earticle

초록

영어

Fucoidan is a marine sulphated polysaccharides of cell-wall matrix of brown algae, containing large proportions of L-fucose and sulphate, together with minor amounts of other sugars like xylose, galactose, glucose, mannose, uronic acid, and rhamnose. For the past years, fucoidan has been extensively studied due to its numerous biological activities such as anticancer, anticoagulant, antithrombotic, antiinflammatory and antiviral. However, the whitening activity of fucoidan has not been elucidated yet. This study was to identify the depigmenting effect of crude fucoidan isolated from the sporophyll of Korean brown seaweeds Undaria pinnatifida at coastal area of Wando, South Korea. The crude fucoidan was isolated by acidic extraction method. Melanin assay and MTT assay was done to confirm the depigmenting activity in B16F10 melanoma cells and melan-a melanocyte cells. The results showed that the crude fuicoidan exhibit 29% melanin inhibition in B16F10 melanoma cells and 54% melanin inhibition in melan-a melanocyte cells at 100 ㎍/㎖ . In the both cell lines, crude fuicoidan did not showed cell cytotoxicity up to the concentration 100 ㎍/㎖. The crude fucoidan has been purified to determine its structure.

키워드

저자

• Jung Eun KIM [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Hyang-Bok LEE [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Dung Hoang NGUYEN [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• SunA YOON [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Jimin UM [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]
• Eun-Ki KIM [ Dept. of Biological Engineering, Inha University, Incheon, 402-751. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576