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Vitiligo is an acquired pigmentary disorder characterized by areas of depigmented skin resulting from loss of epidermal melanocytes. The prevalence of this disease varies from 0.1% to 2% in various global populations. This is one of the most psychologically devastating skin diseases. Histologically, the predominant finding in the depigmented areas of vitiligo is an absence of epidermal melanocytes. The precise cause of the loss of these epidermal melanocytes is unknown. Autoimmune, neural, biochemical, oxidative stress, autocytotoxic, viral, and melanocytes detachment mechanisms have been proposed to explain the pathogenesis of vitiligo. It is known that the existance of inactive melanoblasts in hair root follicles provide a melanocyte source for repigmentation in Vitiligo. Differentiation and migration of these melanocytes precursors from the outer root sheath of hair follicles into clinically depigmented epidermis is crucial for the repigmentation in Vitiligo therapy. An effective treatment regime has been proposed that would stimulate the inactive melanoblasts in the hair follicle to divide, proliferate and migrate upward along the surface of outer root sheath to the nearby epidermis. To evaluate the potential of herbal candidates in treatment of Vitiligo, we studied its effects on the differentiation, proliferation and migration of melanoblast cellsScreening of natural compounds were carried out by evaluating the effect of plant extracts to induce differentiation of melanoblast to active melanocytes by accessing the melanin production (melanin assay) and proliferation (by MTT assay) in melanoblast cell lines (Melb-a).

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저자

• SangJoo PARK [ Dept. of biotechnology, Inha University, Incheon, 402-751. ]
• Babitha SUMATHY [ Dept. of biotechnology, Inha University, Incheon, 402-751. ]
• Hyang-Bok LEE [ Dept. of biotechnology, Inha University, Incheon, 402-751. ]
• Hoang Nguyen DUNG [ Dept. of biotechnology, Inha University, Incheon, 402-751. ]
• SunA YOON [ Dept. of biotechnology, Inha University, Incheon, 402-751. ]
• Jimin UM [ Dept. of biotechnology, Inha University, Incheon, 402-751. ]
• Jeong-Hyun SHIN [ Dept. of biotechnology, Inha University, Incheon, 402-751. ]
• Eun-Ki KIM [ Dept. of biotechnology, Inha University, Incheon, 402-751. ]

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간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576