Tae-Jong CHAE, O-Deuk KWON, Tae-Joon HWANG, Young-Woo JANG, Sang-Hoon KIM, Gi-Yeon HAN, Hyun-Jung KIM, Chan-Wha KIM
언어
영어(ENG)
URL
https://www.earticle.net/Article/A129572
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원문정보
초록
영어
In most countries, diabetes is the primary cause of end stage renal disease (ESRD). The glomerulus is the main filter of the nephron and is a major target of injury in diabetic nephropathy (DN). Although it is a major target of injury in DN, the mechanism of injury is inadequately understood. In this study, to understand glomerular injury mechanism leading to DN, the differences in STZ-induced rat glomerular proteomes in healthy, 6-weeks and 24-weeks old rats were analyzed via 2-dimensional electrophoresis (2-DE). To demonstrate stage of DN, body weight, blood glucose, and protein urea periodically were measured and pathological changes by Periodic acid-Schiff (PAS) staining were examined. To obtain glomerulus from kidney, magnetic beads were used and glomerular proteomes were analyzed by 2-DE and nano-LC-ESI-MS/MS. As a result, three proteins were down-regulated, one protein was up-regulated in STZ-induced group were compared with the control groups. These proteins will give base of mechanism for glomerular injury in DN.
키워드
Proteomic Analysis of Glomerular Proteins from STZ-Induced Diabetic Nephropathy Rats
저자
Tae-Jong CHAE [ School of Life Sciences and Biotechnology, Korea University, Seoul Korea. ]
O-Deuk KWON [ School of Life Sciences and Biotechnology, Korea University, Seoul Korea. ]
Tae-Joon HWANG [ School of Life Sciences and Biotechnology, Korea University, Seoul Korea. ]
Young-Woo JANG [ School of Life Sciences and Biotechnology, Korea University, Seoul Korea. ]
Sang-Hoon KIM [ School of Life Sciences and Biotechnology, Korea University, Seoul Korea. ]
Gi-Yeon HAN [ School of Life Sciences and Biotechnology, Korea University, Seoul Korea. ]
Hyun-Jung KIM [ School of Life Sciences and Biotechnology, Korea University, Seoul Korea. ]
Chan-Wha KIM [ School of Life Sciences and Biotechnology, Korea University, Seoul Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동