Bo-Young YOO, Hee-Hoon YOON, Youn-Ho SHIN, Kye-Yong SONG, Jung-Keug PARK
언어
영어(ENG)
URL
https://www.earticle.net/Article/A129477
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원문정보
초록
영어
The methods currently used for treating alopecia have some limitations. The number of hair transplantation restricts less than 3 times because total transplantable hair number is no increase. To overcome these problems, researchers have attempted the in vitro culturing of hair follicle cells and implanting these cells in the treatment area. In the present study, culture expanded mesenchymal stem cells (MSCs) that do not possess aggregative activity were used to produce cell-aggregated spheroidal dermal papilla like tissues (DPLTs) with the aid of a special culture condition in vitro, and hair follicle inductive capacity pertinent to the aggregative activity was then evaluated. Isolated and cultivated MSCs from bone marrow and umbilical cord in vitro. After propagated MSCs underwent preconditioning in dermal papilla forming medium (DPFM), then subcultured MSCs formed self-aggregated DPLTs. We compared real human scalp dermal papilla cells (hDPCs) with DPLT employing DPCs, DPLT employing hBM-MSCs and DPLTs employing hUC-MSCs.The DPLTs have the same hair follicle inductive ability as natural dermal papilla (DP) tissue in vitro. As a result, MSCs from bone marrow and umbilical cord may be an applicable and novel cell source for the generation of human hair cell therapy.
키워드
dermal papilla (DP)dermal papilla like tissues (DPLTs)mesenchymal stem cells (MSCs)alopecia
저자
Bo-Young YOO [ Dongguk University Research Center of Biotechnology, Seoul, Korea, 100-715. ]
Hee-Hoon YOON [ Dongguk University Research Center of Biotechnology, Seoul, Korea, 100-715. ]
Youn-Ho SHIN [ Dept. Pathology, College of Medicine, Chung-ang University, Seoul, 156-756. ]
Kye-Yong SONG [ Dept. Pathology, College of Medicine, Chung-ang University, Seoul, 156-756. ]
Jung-Keug PARK [ Dept. Medical Biotechnology, Dongguk University, Seoul, 100-715. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동