Acellular bovine amniotic membrane(ABAM) is a biological product which has been used for medical applications including wound dressing. The application of ABAM as a wound dressing provides the prevention of heat and water loss from the wound surface and finally wound healing effect. In this study, the use of ABAM as a cell carrier has been evaluated in order to increase the wound healing efficacy. Keratinocyte was well attached to ABAM and grew on it. When ABAM containing keratinocyte was dressed on the wound induced on SD Rat, the wound healing was enhanced compared with dressing with ABAM only or graft with keratinocyte layer on the wound. In order to further enhance the wound healing effect, fibroblast layer was grafted on the wound, and the ABAM containing keratinocyte was dressed after 3days. The combination of fibroblast and ABAM containing keratinocyte reduced contraction, and enhanced epithelization, angiogenesis and the wound healing. Also ABAM was very bio-compatible and degraded well. Through this study, it was found that ABAM could be an efficient biological cell carrier for wound healing including burn and chronic ulcer. [This work was supported by MKE and KOTEF through the Human Resource Training Project for Strategic Technology.]
키워드
bovine amniotic membrainwound healingskin cell
저자
Narae KIM [ Dept. of Biological Sciences, Hannam University, Daejeon, 305-811. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동