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Enhance the biocompatibility of meural electrode by solvent extraction, drug loading, and surface modification

첫 페이지 보기
  • 발행기관
    한국생물공학회 바로가기
  • 간행물
    한국생물공학회 학술대회 바로가기
  • 통권
    2010 추계학술대회 및 국제심포지움 (2010.10)바로가기
  • 페이지
    pp.231-231
  • 저자
    Jung Bok LEE, Dong Nyoung HEO, Ha Na PARK, Il Keun KWON, Jun Kyo Francis SUH
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A129475

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원문정보

초록

영어
The interface between neural electrodes and neural tissue plays an important role in chronic in vivo recording of neural signal. However, when these devices are implanted in to nerve tissue for recording of neural signal, they lose electrical connectivity due to inflammatory reaction, nonspecific protein adsorption and cell adhesion. In this study, to enhance the short-term and long-term biocompatibility of neural electrode, residual solvent extraction, anti-inflammatory drug loading and surface immobilization processes were carried out. Residual solvent in the neural electrode was reduced by solvent extraction and ultra-sonication processes. To reduce the post-inflammatory reaction, an anti-inflammatory drug embedded in a polyimide (PI) film. To modify the surface of the PI film for reducing protein absorption and cell adhesion, oligo (ethylene glycol) methacrylate (OEGMA) was grafted on the surface of PI films by surface-initiated atom transfer radical polymerization (SI-ATRP). The biocompatibility of the PI film was analyzed using the cytotoxicity, RT-PCR, and H&E staining. Neural electrode that is contained drug show better short term biocompatible characteristics over control neural electrode. These solvent reduction, drug containing, and surface immobilized PI film can be used to increase the biocompatibility of neural electrode.

키워드

Biocompatibility Neural electrode Solvent extraction Drug loading Surface modification

저자

  • Jung Bok LEE [ Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, South Korea. ]
  • Dong Nyoung HEO [ Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, South Korea. ]
  • Ha Na PARK [ Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, South Korea. ]
  • Jun Kyo Francis SUH [ Bionics Program, Korea Institute of Science and Technology, Seoul 136-791, Korea. ]
  • Il Keun KWON [ Department of Maxillofacial Biomedical Engineering & Institute of Oral Biology, School of Dentistry, Kyung Hee University, Seoul 130-701, South Korea. ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
  • 설립연도
    1984
  • 분야
    공학>생물공학
  • 소개
    이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동

간행물

  • 간행물명
    한국생물공학회 학술대회
  • 간기
    반년간
  • 수록기간
    1985~2013
  • 십진분류
    KDC 476 DDC 576

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    피인용수 : 0(자료제공 : 네이버학술정보)

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