Earticle

초록

영어

Cyanobacteria are called as "Cell factory"1) which can produce a wide variety of metabolic compounds. Moreover they are the photosynthetic prokaryote on the earth to release oxygen into the atmosphere with photosystems I and II. Glucose-tolerance Synechocystis sp. PCC 6803 can use organic carbon and inorganic carbon. For analysis of their metabolic network, we constructed the central metabolism based on genome annotation2). With this in silico model, metabolic flux of the model was calculated using flux balance analysis according to its cultivation with various carbon sources and evaluated by fermentation data. Under photoautotrophic culture conditions, fluxes of TCA cycle were distributed similarly with anaerobic E.coli culture. These results were consistent w ith the previous report by Pierce et al in 19673).
It showed under phototrophic culture Synechocystis utilized two biosynthetic pathway to generate Succinyl-CoA and 2-oxoglutarate instead of production of energy. However, in the case of heterotrophic culture, they produced energy using glyoxylate cycle. These results demonstrated how the network of central metabolism in cyanobacteria was working under various trophic culture.

키워드

저자

• Seong-Joo HONG [ Dept. of Biological Engineering, Inha University,Incheon, 402-751. ]
• Jae-Han BAE [ Dept. of Biological Engineering, Inha University,Incheon, 402-751. ]
• Choul-Gyun LEE [ Dept. of Biological Engineering, Inha University,Incheon, 402-751. ]

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간행물

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• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576