Earticle

초록

영어

Many investigators have tried to look for atopic dermatitis medicine from natural resources lately because the occurrence of atopic dermatitis has been continuously increasing. Therefore, an aim of this study is to examine inhibitory effects of pine gnarl water extracts (PGWE) on atopic dermatitis. To conduct this experiment, PGWE was added to splenocytes obtained from OVA-immunized mice for an in-vitro test. In addition, an anti-atopic dermatitis test was carried out by spreading PGWE on the dorsal skin of 2,4dinitrochlorobenzene (DNCB)-induced balb/c mice. It was verified that the IFN-γ, IL-4 and total IgE secretion was suppressed when PGWE was added to splenocytes obtained from OVA-immunized mice. For anti-atopic dermatitis test, PGWE alleviated symptoms of the erythema, crust and dryness in DNCB-induced mice.
Furthermore, the IFN-γ, IL-4 and total IgE secretion of the group treated with PGWE in splenocytes and sera considerably diminished compared to the positive control. Through these results, we can conclude that PGWE can inhibit allergy and atopic dermatitis by modulating IFN-γ, IL-4 cytokine and IgE secretion.

키워드

저자

• Chung-Jo LEE [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Eu-Jin SONG [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Ji-Hee KWAK [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Koth-Bong-Woo-Ri KIM [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Ji-Yeon JUNG [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Min-Ji KIM [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Moon-Kyung CHOI [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Dong-Hyun KIM [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Chan SUNWOO [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]
• Tae-Wan KIM [ Dept. of Food Science and Technology, Andong National University, Gyeongbuk 760-749. ]
• Dong-Hyun AHN [ Dept. of Food Science and Technology, Pukyong National University, Busan 608-737. ]

참고문헌

발행기관

간행물

표지보기 관심저널 등록

• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576