Acer tegmentosum Maxim., a herbal species grown in China and Korea is mainly treated as a medicinal plant and the dried aerial parts have been traditionally used for the treatment of hepatitis, liver cirrhosis, hepatic cancer, leukemia, diabetes mellitus, renal necrosis and edema. Reactive oxygen species, such as O2-, H2O2, and ·OH, mediate reactions which can result in the damage of critical biological molecules including DNA and cellular protein. In this study, the extracts of Acer tegmentosum Maxim. with hot-water, ethanol, methanol, and acetone were found to show the antioxidative and hepatoprotective effects in vitro. The cell lines used were HepG2 E47 cells that expressed human CYP2E1 and HepG2 C34 cells which did not express CYP2E1. No cytotoxicity was shown in MTT assay. The cell viability was measured to decide the proper sample concentration. Antioxidant activities by extracts from Acer tegmentosum Maxim. were investigated by the 2', 7'-Dichlorodihydrofluorescein diacetate(DCFDA)assay and GSH assay.
키워드
Acer tegmentosum MaximAntioxidanthepatoprotective
저자
Jung-Woon PAHK [ Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea. ]
Woo-Cheol JEONG [ Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea. ]
Eock-Kee HONG [ Department of Bioengineering and Technology, Kangwon National University, Chuncheon 200-701, Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동