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The Effect of Powder and Water Extracts of Sparassis Crispa on Immunostimulatory Activity
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- 발행기관
- 한국생물공학회 바로가기
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- 간행물
- 한국생물공학회 학술대회 바로가기
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- 통권
- 2010 추계학술대회 및 국제심포지움 (2010.10)바로가기
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- 페이지
- pp.204-204
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- 저자
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- 언어
- 영어(ENG)
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- URL
- https://www.earticle.net/Article/A129401
※ 원문제공기관과의 협약기간이 종료되어 열람이 제한될 수 있습니다.
원문정보
초록
- 영어
- The precedent studies of Sparassis Crispa (SC) as immunostimulator were conducted mainly using Sparassis crispa glucan (SCG, β-glucan), a bioactive component, and there is a difficulty in commercializing SC as a food in economic aspects, since the extract yield of SC using extraction method applied to foods is too low. Thus, in this study, we have tried to prove the immunostimulatory effect of SC suitable for commercialization in consideration of economic value. The aim for this study was to obtain the beneficial effect on powder (contains about 30% of β-glucan) and water extracts (contains about 10% of β-glucan) of SC which were extracted at various temperatures as immunostimulator in BALB/C mice at 6 weeks of age. The powder and water extracts of SC were orally treated every day for 8 weeks and the secreted cytokines (IL-2, IL-4, IL-12, IFN- γ, and TNF-α) in the blood were measured by ELISA kit. The results show that the SC treatment has led to the increased levels (2~5 times higher) of cytokines (such as IL-2, IL-12 and IFN- γ) compared to the normal control group, as well as the increased level of IL-4 (2.7 times higher at max.), associated with Th1 and Th2 immune after 5~8 weeks. In addition, the level of TNF-α that controls immune response by inducing the creation of many kinds of cytokine has increased by 3.7 times higher with the SC treatment. Especially, it was found that SC powder was more effective than water extracts in immunostimulatory activity and this immunostimulatory effect of SC was proved similar to that of red ginseng (positive control), a typical health food. The results also suggest that SC can be considered as a useful, high value-added food material with the function of immunostimulator.
키워드
Sparassis Crispa Cytokine Immunostimulator저자
간행물 정보
발행기관
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- 발행기관명
- 한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
- 설립연도
- 1984
- 분야
- 공학>생물공학
- 소개
- 이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다 1. 생물공학 분야의 발전을 위한 연구 협력 2. 생물공학의 실용화를 촉진시키기 위한 산학 협동 3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최 4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간 5. 생물공학 발전을 위한 정책 건의 6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동
간행물
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- 간행물명
- 한국생물공학회 학술대회
- 간기
- 반년간
- 수록기간
- 1985~2013
- 십진분류
- KDC 476 DDC 576
이 권호 내 다른 논문 / 한국생물공학회 학술대회 2010 추계학술대회 및 국제심포지움
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