Earticle

초록

영어

Polyene macrolides are mostly produced by Streptomycetes and some other soil bacteria and exert their fungicidal action via interaction with membrane sterols, resulting in the formation of highly organized hydrophilic channels, through which small molecules and ions can leak out. Using the genomics-guided polyene screening method, a rare actinomycetes called Pseudonocardia autotrophica was previously identified to contain a functionally-clustered nystatin-like biosynthetic genes and to produce a presumably novel polyene compound named NPP. Many previous researches revealed that modification of the polyene structure through engineering of its biosynthetic genes is a promising strategy for the production of novel polyene derivatives suitable for potential pharmaceuticals. In our research, we have obtained new derivatives by engineering of genes related with both early and late stages of NPP biosynthetic pathways. This biosynthetic modification approach is already yielding sufficient amount of novel materials for testing the toxicity and bioactivity, thus opening possibilities for discovery of drug-leads for development of effective and safe pharmaceuticals.

키워드

저자

• Mi-Jin LEE [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]
• Kyuboem HAN [ CHA BIO & DIOSTECH Bio Pharmaceutical Research Institute, 461-6 Jeonmin-dong, Yuseong, Daejeon 305-811, Korea. ]
• Eung-Soo KIM [ Department of Biological Engineering, Inha University, Incheon 402-751, Korea. ]

참고문헌

발행기관

간행물

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• 간행물명

  한국생물공학회 학술대회

• 간기

  반년간

• 수록기간

  1985~2013

• 십진분류

  KDC 476 DDC 576