Min Young KIM, Tae Woo LEE, Yong Jae JEON, Hyohak SONG, Jeong Wook LEE, Sang Yup LEE
언어
영어(ENG)
URL
https://www.earticle.net/Article/A129353
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원문정보
초록
영어
Economical viability and natural potential as a carbon source have motivated engineering Mannheimia succiniciproducens for the production of succinic acid through glycerol fermentation1. The methods of rational approaches and adaptive evolution were used to improve the ability of utilization of glycerol as a carbon source in M. succinicproducens. The performance of engineered strains such as PALK-glpA, PALK-glpAcrp, PALK -glpFKA, and PALK-sldABdhaK was better than that of control strain in batch fermentation experiments Above all, in fed-batch fermentation, the most productive strain harboring C.acetobutylicum ATCC824 glycerol 3-phosphate dehydrogenase, and M.succiniciproducens cAMP receptor protein increased both concentration and productivity of succinic acid. Surprisingly, expression of the genes encoding the glycerol dehydrogenase and dihydroxyacetone kinase from G.oxydans was able to improve the rate of glycerol utilization and the production of succinic acid significantly as previously reported in E.coli. [This work was supported by the Genome-Based Integrated Bioprocess Development Project (20100002111) of the Ministry of Education, Science and Technology (MEST) through the National Research Foundation of Korea. Further support by WCU (World Class University) program by MEST (R322009000101420) is appreciated.]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동