Streptomyces which is Gram‐positive, filamentous and soil dwelling bacteria produce various secondary metabolites including antibiotics, peptides and various pigments 1. In the research of Streptomyces, study of regulators related to producing antibiotics has potential to supplement the existing method like random mutagenesis and change more global metabolic flux than single enzyme in metabolic pathway. In addition, many examples of regulators such as ActII‐ORF4 of S. coelicolor 2, StrR of S. griseus 3 and DnrI of S. peucetius 4, TylS and TylR from S. fradiae 5, WblA from S. peucetius 6 also show possibility that the results of characterizing regulators can be applied to develop more efficient industrial strain by directly up‐ and down‐regulating antibiotic biosynthetic gene clusters. To find out unknown regulators affecting primary and secondary metabolisms in Streptomyces coelicolor, we applied different omics approaches for screening of regulators and characterization of new regulators, and characterized several regulators such as NdgR and AbsC.
저자
Yung-Hun YANG [ Department of Microbial Engineering, College of Engineering, Konkuk University, Seoul, Korea. ]
한국생물공학회 [The Korean Society for Biotechnology and Bioengineering]
설립연도
1984
분야
공학>생물공학
소개
이 법인은 생물 공학의 발전과 보급에 이바지하고, 회원 상호 간의 연구 협력과 친목을 도모함을 목적으로 한다
1. 생물공학 분야의 발전을 위한 연구 협력
2. 생물공학의 실용화를 촉진시키기 위한 산학 협동
3. 학술연구 발표회, 강연회, 연수회 등 학술활동의 개최
4. 국,영문 학술지,소식지,학술회의 Proceedings 및 학술도서의 발간
5. 생물공학 발전을 위한 정책 건의
6. 기타 국제 교류 등 본 학회의 목적 달성을 위한 제반 활동