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Effects of Reactive Oxygen Species (ROS) on Sperm Function and Plasminogen Activator Activity in Porcine Spermatozoa

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  • 발행기관
    한국동물생명공학회(구 한국동물번식학회) 바로가기
  • 간행물
    Reproductive & developmental biology 바로가기
  • 통권
    Volume 34 No 3 (2010.09)바로가기
  • 페이지
    pp.185-191
  • 저자
    Soo-Jin Sa, Chun-Keun Park, In-Cheul Kim, Seung-Hoon Lee, Oh-Sub Kwon, Myung-Jick Kim, Kyu-Ho Cho, Dy-Wan Kim, Kyoung-Min So, Hee-Tae Cheong
  • 언어
    영어(ENG)
  • URL
    https://www.earticle.net/Article/A128411

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원문정보

초록

영어
Plasminogen activators (PAs) are serine protease that cleave plasminogen to form the active protease plasmin and may participate in mammalian fertilization. Although correlations have been reported between reactive oxygen species (ROS) and sperm function, the relationship between PA activity and ROS is unknown. We determined the effects of ROS on sperm function and PA activities in boar spermatozoa preincubated under the X-XO system. When spermatozoa were treated with the X+XO group, a significant increase (p<0.05) was observed in the percentage of acrosome reacted spermatozoa compared with that of the control group. However, when antioxidants were added to the medium with X+XO, the rate of acrosome reaction tended to decrease. Also, a significantly lower percentage of acrosome reacted spermatozoa was observed in the X+XO+catalase group at 6 hr of incubation compared with that of X+XO group. The density of malondialdehyde (MDA) was higher in the X+XO group than in different treatment groups. In another experiment, incubation of spermatozoa in medium with X+XO was associated with a significant (p<0.05) increase in activity of tPA-PAI and tPA compared with the control group. Antioxidants decreased the increased activity of tPA-PAI and tPA by preincubation in the X-XO system. Also, a significantly lower (p<0.05) activities of tPA-PAI and tPA were observed in the X+XO+catalase group compared with the X+XO group. No significant differences, however, were observed in the activity of uPA. These results suggest that the increase of acrosome reaction by the X-XO system resulted in increase of PAs activity in the sperm incubation medium.

목차

ABSTRACT
 INTRODUCTION
 MATERIALS AND METHODS
 RESULTS
 DISCUSSION
 REFERENCES

키워드

Plasminogen activators (PAs) Reactive oxygen species (ROS) Spermatozoa Pig

저자

  • Soo-Jin Sa [ Seine Science Division, National Institute of Animal Science ] Corresponding author
  • Chun-Keun Park [ College of Animal Life Science ]
  • In-Cheul Kim [ Science Division, National Institute of Animal Science ]
  • Seung-Hoon Lee [ Science Division, National Institute of Animal Science ]
  • Oh-Sub Kwon [ Science Division, National Institute of Animal Science ]
  • Myung-Jick Kim [ Science Division, National Institute of Animal Science ]
  • Kyu-Ho Cho [ Science Division, National Institute of Animal Science ]
  • Dy-Wan Kim [ Science Division, National Institute of Animal Science ]
  • Kyoung-Min So [ Science Division, National Institute of Animal Science ]
  • Hee-Tae Cheong [ Veterinary Medicine, Kangwon National University ]

참고문헌

자료제공 : 네이버학술정보

간행물 정보

발행기관

  • 발행기관명
    한국동물생명공학회(구 한국동물번식학회) [The Korean Society of Animal Reproduction and Biotechnology]
  • 설립연도
    1976
  • 분야
    농수해양>축산학
  • 소개
    동물번식생리학, 동물생명공학, 수의학, 인공수정 및 수정란이식을 이용한 동물개량에 관한 이론과 기술의 발전을 통해 학계, 연구계, 산업계 및 양축가 상호간의 협력을 도모함으로써 동물과학발전 및 사회일반의 이익에 기여 한다는 목적을 위해 노력해 나가겠습니다.

간행물

  • 간행물명
    Reproductive & developmental biology
  • 간기
    계간
  • pISSN
    1738-2432
  • eISSN
    2288-0151
  • 수록기간
    1977~2018
  • 십진분류
    KDC 527 DDC 636

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